ABSTRACT
The anti-tumor necrosis factor (TNF) monoclonal antibody infliximab inhibits the pleiotropic actions of TNF and is widely used for the treatment of inflammatory diseases, such as uveitis. A pathogenetic role of TNF in ocular inflammatory conditions has recently emerged. The authors describe a patient with collagen mixed disease who had decreased vision in the left eye. Fundus examination disclosed bilateral peripheral vasoproliferative tumors and macular edema in the left eye. The patient underwent treatment with infliximab intravenously for his systemic condition. Regression of the vasoproliferative tumors in both eyes and improvement of macular edema in the left eye was observed. Although the data are limited, anti-TNF antibodies such as infliximab may be useful in the treatment of retinal vascular tumors. [Ophthalmic Surg Lasers Imaging 2008;39:348-349.]
AUTHORS
From Pedro Ernesto University Hospital (RMJ, OFMB, ALC), State University of Rio de Janeiro, Rio de Janeiro; and the Vision Institute (OFMB, ECD), Federal University of São Paulo, São Paulo, Brazil.
Accepted for publication February 14, 2008.
Address correspondence to Ricardo M. Japiassú, MD, Rua Desembargador Isidro 121 APTO. 202-B – Tijuca, Rio de Janeiro – RJ, CEP 20521-160, Brazil.
