BACKGROUND AND OBJECTIVE
To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using auto fluorescence (FAF).
PATIENTS AND METHODS
Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared.
RESULTS
GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area.
CONCLUSION
SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.
[Ophthalmic Surg Lasers Imaging 2008;39:S8-S14.]
AUTHORS
From the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (BJL, PJR, GG, FW, RWK, WJF, CAP); and the Department of Ophthalmology, Shanghai Jiaotong University, First People’s Hospital, Shanghai, China (FW).
Accepted for publication March 13, 2008.
The authors would like to acknowledge research funding from the 2006 Allergan Horizon Grant Program and the H.A. & Mary K. Chapman Charitable Trust. Additional research funding provided by an unrestricted grant from Research to Prevent Blindness, Inc., New York, NY, NEI core grant P30 EY014801, and Carl Zeiss Meditec, Inc., Dublin, CA.
Dr. Puliafito did not participate in the editorial review or decision of this manuscript.
Address correspondence to Philip J. Rosenfeld, MD, PhD, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136.
