BACKGROUND AND OBJECTIVE
To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF).
PATIENTS AND METHODS
Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared.
RESULTS
GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area.
CONCLUSION
SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.
[Ophthalmic Surg Lasers Imaging 2009;40:96-101.]
AUTHORS
From the Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida (BJL, PJR, GG, FW, RWK, WJF, CAP); and the Department of Ophthalmology, Shanghai Jiaotong University, First People’s Hospital, Shanghai, China (FW).
Accepted for publication March 13, 2008.
Supported by research grants from NEI (RO3 EY016420), NEI core center grant P30 EY014801 to the University of Miami, and Research to Prevent Blindness, Inc. Additional research funding was received from Carl Zeiss Meditec, Inc.
Dr. Lujan received support from a grant to the University of Miami from Carl Zeiss Meditec, Inc. Drs. Gregori, Knighton, and Rosenfeld received research support from Carl Zeiss Meditec, Inc. Drs. Gregori, Knighton, and Puliafito own a patent that is licensed to Carl Zeiss Meditec, Inc. Dr. Puliafito is also a research and clinical consultant for Carl Zeiss Meditec, Inc. Dr. Rosenfeld received an honorarium from Carl Zeiss Meditec, Inc. Drs. Wang and Feuer have no financial or proprietary interest in the materials presented herein.
Dr. Puliafito did not participate in the editorial review of this manuscript.
Address correspondence to Philip J. Rosenfeld, MD, PhD, University of Miami Miller School of Medicine, 900 NW 17th Street, Miami, FL 33136.
